CELLULAR-POLARIZATION INDUCED BY CHEMOKINES - A MECHANISM FOR LEUKOCYTE RECRUITMENT

chemokines are known to induce leukocyte adhesion to the endothelium a nd emigration into tissues. Here, Miguel Angel del Pozo and colleagues discuss how these molecules also appear to regulate the redistributio n of cell adhesion receptors. Recruitment of adhesion molecules toward s a cellular uropod in response to chemokines may represent a novel co operative mechanism in the recruitment of leukocytes to sites of infla mmation.