F. Pedeutour et al., TRANSLOCATION, T(17-22)(Q22-Q13), IN DERMATOFIBROSARCOMA PROTUBERANS - A NEW TUMOR-ASSOCIATED CHROMOSOME REARRANGEMENT, Cytogenetics and cell genetics, 72(2-3), 1996, pp. 171-174
A translocation, t(17;22)(q22;q13), was identified in two cases of der
matofibrosarcoma protuberans (DP). They bring to four the number of DP
cases characterized by an identical t(17;22)(q22;q13), which can be c
onsidered as a new tumor-associated chromosome rearrangement. To date,
this translocation has been found only in DP and its juvenile form, g
iant-cell fibroblastoma. This finding has two major consequences. Firs
t, it casts light on the development and significance in DP of ring ch
romosomes which consistently harbor sequences derived from chromosomes
17 and 22. Second, the identification of this new chromosome marker,
and eventually of the underlying molecular rearrangement, should help
to classify DP, a soft-tissue tumor of still uncertain cell origin. In
addition, it could be used to differentiate DP from truly benign or m
alignant entities, in order that this tumor of intermediate malignancy
could be adequately managed.