CORRECTION OF THE SPONTANEOUS AND DEB-INDUCED CHROMOSOMAL-ABERRATIONSIN FANCONI-ANEMIA CELLS OF THE FA(C) COMPLEMENTATION GROUP BY THE FACC GENE

Authors
STAVROPOULOS DJ SOOD S TOMKINS DJ BUCHWALD M
Citation
Dj. Stavropoulos et al., CORRECTION OF THE SPONTANEOUS AND DEB-INDUCED CHROMOSOMAL-ABERRATIONSIN FANCONI-ANEMIA CELLS OF THE FA(C) COMPLEMENTATION GROUP BY THE FACC GENE, Cytogenetics and cell genetics, 72(2-3), 1996, pp. 194-196
Citations number
11
Categorie Soggetti
Cell Biology","Genetics & Heredity
Journal title
Cytogenetics and cell genetics → ACNP
ISSN journal
03010171
Volume
72
Issue
2-3
Year of publication
1996
Pages
194 - 196
Database
ISI
SICI code
0301-0171(1996)72:2-3<194:COTSAD>2.0.ZU;2-5
Abstract
Fanconi anemia (FA) cells are hypersensitive to the cytotoxic and clas togenic effects of DNA cross-linking agents. Four complementation grou ps have been identified to date. The gene (FACC) that corrects the hyp ersensitivity of one of them, FA(C), has been cloned. In the present s tudy, both the increased spontaneous and diepoxybutane (DEB)-induced c hromosomal instability in FA(C) lymphoblastoid cells were corrected by transfection of FACC.