REGIONAL MAPPING OF THE HUMAN PLATELET-ACTIVATING-FACTOR RECEPTOR GENE (PTAFR) TO 1P35-]P34.3 BY FLUORESCENCE IN-SITU HYBRIDIZATION

The human platelet-activating factor cell-surface receptor (PTAFR) is a G protein-coupled receptor thought to contribute to many atopic and inflammatory diseases and, perhaps, to the growth of some neoplasms. E xploring the possibility that the PTAFR might be involved in the genet ic predisposition to any disease requires knowledge of its chromosomal localization. In this paper we have used a 20-kb human genomic fragme nt containing the coding sequence ofthe cloned PTAFR to determine the regional chromosomal localization of the gene. Using fluorescence in s itu hybridization, the localization ofthe human PTAFR gene was mapped to lp35 --> p34.3.