THE INFLUENCE OF PROLONGED ANTIDEPRESSANT TREATMENT ON THE CHANGES INCYCLIC-AMP ACCUMULATION INDUCED BY EXCITATORY AMINO-ACIDS IN RAT CEREBRAL CORTICAL SLICES

WE investigated the effect of prolonged electroconvulsive shock (ECS) or imipramine treatment on cyclic AMP accumulation induced by ibotenat e and glutamate in rat cerebral cortical slices. Prolonged imipramine or electroconvulsive shock treatment attenuated the ibotenate-induced increase in cyclic AMP accumulation and inhibited the synergistic inte raction between ibotenate and noradrenaline; the glutamate-mediated in hibition of forskolin-stimulated cyclic AMP accumulation was not modif ied Our results indicate that multiple effects of excitatory amino aci ds on cyclic AMP accumulation are modified differently by antidepressa nt treatment.