H. Bengtsson et al., EXPRESSION OF ACTIVIN RECEPTORS TYPE-I AND TYPE-II ONLY PARTIALLY OVERLAPS IN THE NERVOUS-SYSTEM, NeuroReport, 7(1), 1995, pp. 113-116
IN situ hybridization was used to localize mRNA encoding two cooperati
ve serine/threonine kinase receptors. Activin receptor IIA mRNA in the
adult rat brain is highly expressed in the dentate gyrus, in the pyra
midal neurones of CA3 and CA1, in the entorhinal cortex, in the cortic
al amygdaloid nucleus and in the amygdalo-hippocampal area. In the E16
rat embryo, labelling was found in the dorsal root ganglion neurones
and in the spinal cord. Activin type I receptor (ALK-2/R-1) labelling
was also localized to the hippocampal formation but with an even distr
ibution over the granular cells of the dentate gyrus, the CA3 and CA1
pyramidal neurones, while no labelling was found in the entorhinal or
amygdaloid areas. In the E16 rat no neuronal labelling was found. The
incomplete overlap of these two expression patterns suggests that thes
e receptors may locally have other partners for forming signalling rec
eptor complexes.