ANTIFUNGAL PROPERTIES OF 3-METHYL-5-AMINOISOXAZOLE-4-THIOCYANATE ON 4YEASTS - AN UNUSUAL DOSE-DEPENDENT EFFECT ON RHODOTORULA-GLUTINIS HARRISON

Authors
MARES D ROMAGNOLI C DONINI A BRUNI A
Citation
D. Mares et al., ANTIFUNGAL PROPERTIES OF 3-METHYL-5-AMINOISOXAZOLE-4-THIOCYANATE ON 4YEASTS - AN UNUSUAL DOSE-DEPENDENT EFFECT ON RHODOTORULA-GLUTINIS HARRISON, Canadian journal of microbiology, 42(2), 1996, pp. 191-195
Citations number
15
Categorie Soggetti
Microbiology,Immunology,"Biothechnology & Applied Migrobiology",Biology
Journal title
Canadian journal of microbiology → ACNP
ISSN journal
00084166
Volume
42
Issue
2
Year of publication
1996
Pages
191 - 195
Database
ISI
SICI code
0008-4166(1996)42:2<191:APO3O4>2.0.ZU;2-9
Abstract
The antifungal activity of 3-methyl-5-aminoisoxazole-4-thiocyanate was studied on Candida albicans, Saccharomyces cerevisiae, Schizosaccharo myces pombe, and Rhodotorula glutinis. A significant inhibition of gro wth was evident in all yeasts. The ultrastructural modifications have demonstrated that the compound at half-minimum inhibitory concentratio n (MIC) dose (1.25 mu g . mL(-1)) causes the transformation of R. glut inis from yeast to mycelium form by the formation of a germ tube. The accumulation of abnormal amounts of wall substances after treatment wi th the MIC is discussed in relation to ergosterol and chitin productio n.