MILBEMYCINS ALPHA(11), ALPHA(12), ALPHA(13), ALPHA(14) AND ALPHA(15) - A NEW FAMILY OF MILBEMYCINS FROM STREPTOMYCES-HYGROSCOPICUS SUBSP AUREOLACRIMOSUS - TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE ELUCIDATION AND BIOLOGICAL PROPERTIES

Authors
TAKAHASHI S MIYAOKA H TANAKA K ENOKITA R OKAZAKI T
Citation
S. Takahashi et al., MILBEMYCINS ALPHA(11), ALPHA(12), ALPHA(13), ALPHA(14) AND ALPHA(15) - A NEW FAMILY OF MILBEMYCINS FROM STREPTOMYCES-HYGROSCOPICUS SUBSP AUREOLACRIMOSUS - TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE ELUCIDATION AND BIOLOGICAL PROPERTIES, Journal of antibiotics, 46(9), 1993, pp. 1364-1371
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
46
Issue
9
Year of publication
1993
Pages
1364 - 1371
Database
ISI
SICI code
0021-8820(1993)46:9<1364:MAAAAA>2.0.ZU;2-U
Abstract
Streptomyces hygroscopicus subsp. aureolacrimosus SANK 60286 produces a new family of milbemycins, named milbemycins alpha11, beta12, alpha1 3, alpha14 and alpha15, together with other milbemycins. Their structu res are 3-methyl-2-butenoyloxy and 3-methylbutyroyloxy derivatives at C-4a of milbemycins A3 and A4, or 3-methyl-2-pentenoyloxy derivative a t C-4a of milbemycin A3, respectively. Milbemycin alpha14, 3-methyl-2- butenoyloxy derivative, especially possesses a potent acaricidal activ ity.