THE SUBTHALAMIC NUCLEUS - A POSSIBLE TARGET FOR STEREOTAXIC SURGERY IN PARKINSONS-DISEASE

Authors
GURIDI J LUQUIN MR HERRERO MT OBESO JA
Citation
J. Guridi et al., THE SUBTHALAMIC NUCLEUS - A POSSIBLE TARGET FOR STEREOTAXIC SURGERY IN PARKINSONS-DISEASE, Movement disorders, 8(4), 1993, pp. 421-429
Citations number
72
Categorie Soggetti
Clinical Neurology
Journal title
Movement disorders → ACNP
ISSN journal
08853185
Volume
8
Issue
4
Year of publication
1993
Pages
421 - 429
Database
ISI
SICI code
0885-3185(1993)8:4<421:TSN-AP>2.0.ZU;2-E
Abstract
Hyperactivity in the subthalamic nucleus (STN) projections to the glob us pallidus medialis (GPM) has been established as a crucial feature o f parkinsonism in animal models of Parkinson's disease (PD). Recent ex periments blocking the STN glutamatergic output to GPM or lesioning th e STN support this concept by showing a dramatic reversal of parkinson ism. We review the role of stereotaxic surgery in the past and the pos sible future application of subthalamotomy for PD.