SYNTHESIS OF PYRIDINONE RIBONUCLEOSIDE 3-O-PHOSPHORAMIDITES AND THEIRINCORPORATION INTO OLIGORIBONUCLEOTIDES

Authors
MATULICADAMIC J GONZALEZ C USMAN N BEIGELMAN L
Citation
J. Matulicadamic et al., SYNTHESIS OF PYRIDINONE RIBONUCLEOSIDE 3-O-PHOSPHORAMIDITES AND THEIRINCORPORATION INTO OLIGORIBONUCLEOTIDES, Bioorganic & medicinal chemistry letters, 6(4), 1996, pp. 373-378
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
4
Year of publication
1996
Pages
373 - 378
Database
ISI
SICI code
0960-894X(1996)6:4<373:SOPR3A>2.0.ZU;2-P
Abstract
Protected pyridin-2- and pyridin-4-one ribonucleosides 3 and 9 were sy nthesized using a one-pot reaction of silylated bases with 1-O-acetyl- tri-O-benzoyl-beta-D-ribofuranose (2) in the presence of CF(3)SO(3)SiM e(3) The nucleosides were converted in 4 steps into 3'-O-phosphoramidi tes 7 and 11 which were incorporated into hammerhead ribozyme substrat es using solid-phase phosphoramidite chemistry.