DESIGN, SYNTHESIS AND X-RAY CRYSTALLOGRAPHIC STUDIES OF [7.3.1]MACROCYCLIC AND [8.3.1]MACROCYCLIC FKBP-12 LIGANDS

Authors
BABINE RE BLECKMAN TM LITTLEFIELD ES PARGE HE PELLETIER LAK LEWIS CT FRENCH JV IMBACUAN M KATOH S TATLOCK JH SHOWALTER RE ERNEST J
Citation
Re. Babine et al., DESIGN, SYNTHESIS AND X-RAY CRYSTALLOGRAPHIC STUDIES OF [7.3.1]MACROCYCLIC AND [8.3.1]MACROCYCLIC FKBP-12 LIGANDS, Bioorganic & medicinal chemistry letters, 6(4), 1996, pp. 385-390
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
4
Year of publication
1996
Pages
385 - 390
Database
ISI
SICI code
0960-894X(1996)6:4<385:DSAXCS>2.0.ZU;2-V
Abstract
The design, synthesis, and structure activity relationships of a serie s of novel macrocyclic FKBP-12 ligands 1 are reported. The crystal str ucture of the complex between 7 and human FKBP-12 is reported and some SAR results are discussed based on this complex.