UNSATURATED THIOACETIC ACIDS AS NOVEL MECHANISM - BASED INHIBITORS OFPEPTIDYLGLYCINE ALPHA-HYDROXYLATING MONOOXYGENASE

Authors
CASARA P GANZHORN A PHILIPPO C CHANAL MC DANZIN C
Citation
P. Casara et al., UNSATURATED THIOACETIC ACIDS AS NOVEL MECHANISM - BASED INHIBITORS OFPEPTIDYLGLYCINE ALPHA-HYDROXYLATING MONOOXYGENASE, Bioorganic & medicinal chemistry letters, 6(4), 1996, pp. 393-396
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
4
Year of publication
1996
Pages
393 - 396
Database
ISI
SICI code
0960-894X(1996)6:4<393:UTAANM>2.0.ZU;2-C
Abstract
Several unsaturated thioacetic acids were synthesized as potential mec hanism-based inhibitors of peptidylglycine alpha-hydroxylating monooxy genase (PHM) prepared from horse serum. Trans-styrylthioacetic acid pr oduced potent time-dependent inhibition of PHM. Potential mechanisms a re proposed to explain PHM inactivation by unsaturated thioacetic acid s.