THE SMOOTH-MUSCLE CELL ANTIPROLIFERATIVE ACTIVITY OF HEPARAN-SULFATE MODEL OLIGOSACCHARIDES

Authors
WESSEL HP IBERG N
Citation
Hp. Wessel et N. Iberg, THE SMOOTH-MUSCLE CELL ANTIPROLIFERATIVE ACTIVITY OF HEPARAN-SULFATE MODEL OLIGOSACCHARIDES, Bioorganic & medicinal chemistry letters, 6(4), 1996, pp. 427-430
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
4
Year of publication
1996
Pages
427 - 430
Database
ISI
SICI code
0960-894X(1996)6:4<427:TSCAAO>2.0.ZU;2-0
Abstract
Heparan sulfate model oligosaccharides were devised with the simplyfyi ng assumptions that i) carboxyl-reduction and subsequent sulfation of heparan sulfate does not decrease the SMC antiproliferative activity, and ii) N-Sulfates in glucosamines can be replaced by O-sulfates. Thes e heparan sulfate model oligosaccharides are more active than analogou s heparin fractions.