1-HYDROXY-1,4-DIHYDROQUINOXALINE-2,3-DIONES - NOVEL ANTAGONISTS AT NMDA RECEPTOR GLYCINE SITES

Authors
ZHENG H ESPITIA SA ILYIN V HAWKINSON JE WOODWARD RM WEBER E KEANA JFW
Citation
H. Zheng et al., 1-HYDROXY-1,4-DIHYDROQUINOXALINE-2,3-DIONES - NOVEL ANTAGONISTS AT NMDA RECEPTOR GLYCINE SITES, Bioorganic & medicinal chemistry letters, 6(4), 1996, pp. 439-440
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
4
Year of publication
1996
Pages
439 - 440
Database
ISI
SICI code
0960-894X(1996)6:4<439:1-NAAN>2.0.ZU;2-S
Abstract
A series of 1-hydroxy-1,4-dihydroquinoxaline-2,3-diones was synthesize d and assayed for NMDA receptor glycine site antagonism. Except for 4a , these were found to be 3-80 times weaker antagonists than the analog ous 1,4-dihydroquinoxaline-2,3-diones.