J-104,123, A NOVEL AND ORALLY-ACTIVE INHIBITOR OF SQUALENE SYNTHASE -STEREOSELECTIVE SYNTHESIS AND CHOLESTEROL-LOWERING EFFECTS IN DOGS
Citation
Y. Iwasawa et al., J-104,123, A NOVEL AND ORALLY-ACTIVE INHIBITOR OF SQUALENE SYNTHASE -STEREOSELECTIVE SYNTHESIS AND CHOLESTEROL-LOWERING EFFECTS IN DOGS, Bioorganic & medicinal chemistry letters, 6(4), 1996, pp. 463-466
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
SICI code
0960-894X(1996)6:4<463:JANAOI>2.0.ZU;2-C
Abstract
J-104,123, a potent inhibitor of squalene synthase having monocarboxyl
ic acid structure, was discovered by chemical modification of J-104,11
8. An oral dose of J-104,123 lowered serum cholesterol levels in dogs.
J-104,123 was synthesized stereoselectively from methyl (R)-3-hydroxy
butyrate.
