SYNTHESIS AND BIOLOGICAL EVALUATION OF A NEW SERIES OF DIHYDROFOLATE-REDUCTASE INHIBITORS BASED ON THE 4-(2,6-DIAMINO-5-PYRIMIDINYL)ALKYL-L-GLUTAMIC ACID STRUCTURE

Authors
GOSSETT LS HABECK LL GATES SB ANDIS SL WORZALLA JF SCHULTZ RM MENDELSOHN LG KOHLER W RATNAM M GRINDEY GB SHIH CA
Citation
Ls. Gossett et al., SYNTHESIS AND BIOLOGICAL EVALUATION OF A NEW SERIES OF DIHYDROFOLATE-REDUCTASE INHIBITORS BASED ON THE 4-(2,6-DIAMINO-5-PYRIMIDINYL)ALKYL-L-GLUTAMIC ACID STRUCTURE, Bioorganic & medicinal chemistry letters, 6(4), 1996, pp. 473-476
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
4
Year of publication
1996
Pages
473 - 476
Database
ISI
SICI code
0960-894X(1996)6:4<473:SABEOA>2.0.ZU;2-O
Abstract
A novel series of dihydrofolate reductase inhibitors was uncovered dur ing an expansion of the SAR of 5,10-dideazatetrahydrofolic acid, and t heir biological activity was evaluated. These new analogs do not posse ss an oxygen at the 4 position and contain a monocyclic pyrimidine rin g.