SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 4-METHOXY AND 8-METHOXY TRINEMS

Authors
ANDREOTTI D ROSSI T GAVIRAGHI G DONATI D MARCHIORO C DIMODUGNO E PERBONI A
Citation
D. Andreotti et al., SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 4-METHOXY AND 8-METHOXY TRINEMS, Bioorganic & medicinal chemistry letters, 6(4), 1996, pp. 491-496
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
4
Year of publication
1996
Pages
491 - 496
Database
ISI
SICI code
0960-894X(1996)6:4<491:SAAAO4>2.0.ZU;2-E
Abstract
The synthesis of all the isomers of zatricyclo-[7.2.0.0(3,8])-undec-2- ene-carboxylates 2 and zatricyclo-[7.2.0.0(3.8)]-undec-2-ene-carboxyla tes 3 is described. The biological data obtained indicated that the (4 S,8S)-4-methoxy derivative (3b) is the best compound in terms of micro biological activity, breadth of spectrum of action and stability to hy drolytic enzymes, namely beta-lactamases.