INDUCING PROPERTIES OF RIFABUTIN, AND EFFECTS ON THE PHARMACOKINETICSAND METABOLISM OF CONCOMITANT DRUGS

Authors
BENEDETTI MS
Citation
Ms. Benedetti, INDUCING PROPERTIES OF RIFABUTIN, AND EFFECTS ON THE PHARMACOKINETICSAND METABOLISM OF CONCOMITANT DRUGS, Pharmacological research, 32(4), 1995, pp. 177-187
Citations number
48
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Pharmacological research → ACNP
ISSN journal
10436618
Volume
32
Issue
4
Year of publication
1995
Pages
177 - 187
Database
ISI
SICI code
1043-6618(1995)32:4<177:IPORAE>2.0.ZU;2-3
Abstract
Rifabutin, a rifamycin derivative like rifampicin, has been registered for the treatment of pulmonary tuberculosis and for the prophylaxis a nd treatment of MAC in patients with AIDS. Rifabutin induces cytochrom e P-450 3A4. The effect of rifabutin on the pharmacokinetics and metab olism of drugs administered concomitantly to humans (isoniazid, ethamb utol, zidovudine, didanosine, delavirdine, fluconazole, itraconazole, methadone, clarithromycin, theophylline and cyclosporin) has been revi ewed. (C) 1995 The Italian Pharmacological Society