ACUTE HEMORRHAGIC CYSTITIS BY ADENOVIRUS TYPE-11 WITH AND WITHOUT TYPE-37 AFTER KIDNEY-TRANSPLANTATION

We report 2 kidney transplant patients with acute hemorrhagic cystitis . Adenovirus type 11 was isolated in the urine of both patients and in 1 patient adenovirus type 37 was also isolated. Each developed macroh ematuria with urgency, micturition pain, elevated fever and functional deterioration of the transplanted kidney possibly due to acute reject ion. These symptoms and laboratory data suggesting renal impairment pe rsisted for approximately 4 weeks after therapy for acute rejection ha d been started without any specific additional treatment for adenoviru s. Serum creatinine levels returned to slightly higher values than bef ore this episode. Histological findings of biopsy specimens from the t ransplanted kidney in 1 patient indicated that renal impairment was at tributable to acute rejection. According to the clinical results of ou r cases, there were no remarkable differences between adenovirus type 1 1 infection with or without type 37 infection. Acute hemorrhagic cys titis caused by the adenovirus is an interesting complication after ki dney transplantation, especially with regard to kidney impairment and treatment.