INCREASED RISK OF LEUKEMIA IN PATIENTS WITH JUVENILE CHRONIC ARTHRITIS TREATED WITH CHLORAMBUCIL

Authors
KAUPPI MJ SAVOLAINEN HA ANTTILA VJ ISOMAKI HA
Citation
Mj. Kauppi et al., INCREASED RISK OF LEUKEMIA IN PATIENTS WITH JUVENILE CHRONIC ARTHRITIS TREATED WITH CHLORAMBUCIL, Acta paediatrica, 85(2), 1996, pp. 248-250
Citations number
15
Categorie Soggetti
Pediatrics
Journal title
Acta paediatrica → ACNP
ISSN journal
08035253
Volume
85
Issue
2
Year of publication
1996
Pages
248 - 250
Database
ISI
SICI code
0803-5253(1996)85:2<248:IROLIP>2.0.ZU;2-H
Abstract
Two cases of acute leukaemia have developed in a group of 77 patients treated with chlorambucil (Chi) because of severe juvenile chronic art hritis. The total follow-up from the beginning of Chi treatment in the se patients was 560 years, indicating a highly increased risk of leuka emia. Despite favourable results, especially in patients with secondar y amyloidosis, Chi should only be used in selected cases.