In adults greater energy expenditure, primarily on physical activity,
is associated with greater leanness. Such an association has proved mo
re difficult to demonstrate in infants, partly due to the difficulty o
f measuring fatness and free living energy expenditure in this age gro
up. Stable isotope techniques now make such investigations more viable
. Objective-The relationship between body composition and energy expen
diture was investigated in 12 week infants. Methods-Total energy expen
diture and fat mass were estimated using the doubly labelled water tec
hnique. Subjects-92 normal healthy infants. Results-Fat mass was corre
lated with both triceps and subscapular skinfold thicknesses (p < 0.00
1). After controlling for body size, age was a significant predictor o
f fat mass (p = 0.003), whereas total energy expenditure was not (p =
0.463). Conclusions-The cross sectional link between activity level an
d fatness in young infants, reported previously, does not persist when
energy expenditure is considered.