I. Alatli et L. Hammarstrom, ROOT SURFACE-DEFECTS IN RAT MOLAR INDUCED BY 1-HYDROXYETHYLIDENE-1,1-BISPHOSPHONATE, Acta Odontologica Scandinavica, 54(1), 1996, pp. 59-65
Cementum surface alterations induced by 1-hydroxyethylidene-1,1-bispho
sphonate (HEBP) in the maxillary first molars in rats were studied by
means of scanning electron microscopy. Single or triple injections of
HEBP inhibit the formation of acellular extrinsic fiber cementum and d
elay the formation of cellular mixed-fiber cementum. The results indic
ate the importance of acellular extrinsic fiber cementum as a protecti
on barrier against root resorption and the different mechanisms underl
ying the formation of the two cementum varieties.