GLYCEROL-3-PHOSPHATE DEHYDROGENASE INHIBITORS, ANACARDIC ACIDS, FROM GINKGO-BILOBA

Authors
IRIE J MURATA M HOMMA S
Citation
J. Irie et al., GLYCEROL-3-PHOSPHATE DEHYDROGENASE INHIBITORS, ANACARDIC ACIDS, FROM GINKGO-BILOBA, Bioscience, biotechnology, and biochemistry, 60(2), 1996, pp. 240-243
Citations number
16
Categorie Soggetti
Biology,Agriculture,"Biothechnology & Applied Migrobiology","Food Science & Tenology
Journal title
Bioscience, biotechnology, and biochemistry → ACNP
ISSN journal
09168451
Volume
60
Issue
2
Year of publication
1996
Pages
240 - 243
Database
ISI
SICI code
0916-8451(1996)60:2<240:GDIAAF>2.0.ZU;2-O
Abstract
Four inhibitors of glycerol-3-phosphate dehydrogenase were isolated fr om Ginkgo biloba and identified as anacardic acids (6-tridecylsalicyli c acid, 6-[(8Z)-pentadecenyl] salicylic acid, 6-[(9Z,12Z)-heptadecadie nyl]salicylic acid, and 6-[(8Z)-heptadecenyl]salicylic acid) by instru mental analyses. Their 50% inhibitory concentrations against the enzym e were 1-3 mu g/ml under the standard assay conditions. Anacardic acid inhibited the enzyme non-competitively. The sarcotesta contained most of anacardic acids, and nuts a little.