BASAL PEPSINOGEN-I LEVELS AND HELICOBACTE R-PYLORI INFECTION IN PATIENTS WITH DUODENAL-ULCER AND NORMAL ENDOSCOPY

Aim: To study basal pepsinogen I levels in patients with duodenal ulce r and in subjects with normal endoscopy, depending on Helicobacter pyl ori status. Methods: One-hundred and one patients with duodenal ulcer and 74 controls with normal endoscopy were studied. Mean age and gende r distribution were: 46 vs 42 years, and 74% vs 43% males, respectivel y, At endoscopy biopsies from the gastric antrum and body were obtaine d for histologic (H&E) and microbiologic (Gram and culture) study. Bas al levels of serum pepsinogen I were measured (RIA).Results: Among the subjects with a normal endoscopy, those with H. pylori infection had higher pepsinogen I levels (m +/- SD) than non-infected patients (77 /- 27 vs 62 +/- 28 ng/ml; p< 0.05). Basal levels in duodenal ulcer pat ients were 107 +/- 38 ng/ml, higher (p< 0.001) than in the group with normal endoscopy (both with and without H. pylori). In multivariate an alysis pepsinogen I levels were correlated with H. pylori infection (r egression coef.= 17; SE= 8.1), duodenal ulcer (regr. coef.= 22; SE= 5. 8) and smoking habit (regr. coef.= 24; SE= 5.2). Conclusion: Basal pep sinogen I levels were significantly higher in duodenal ulcer patients than in H. pylori infected subjects with normal endoscopy. The lowest levels corresponded to non-infected patients. Therefore, an additional factor other than H. pylori infection is likely involved in the hiper pepsinogenaemia classically reported in duodenal ulcer patients.