HEPATOTOXICITY ASSOCIATED WITH DROXICAM

We present four cases of hepatitis with clinical features indicating a direct link with Droxicam. In all the cases, the presentation was tha t of acute hepatitis with subsequent resolution, whereas one patient d eveloped autoimmune chronic active hepatitis. A full evaluation includ ing ultrasound, liver biopsy, and serologic markers supported the diag nosis. Due to the fact that the <<Direccibn General de Farmacia y Prod uctos Sanitarios>> has approved the postponement of dispensation of pr oducts with Droxicam from February 15, 1995, this drug should not be c onsidered anymore in the future as a potential cause of liver injury ( acute or chronic hepatitis).