SEQUENCES OF THE GENES ENCODING THE A-SUBUNIT, B-SUBUNIT AND C-SUBUNIT OF THE HAEMOPHILUS-INFLUENZAE DIMETHYLSULFOXIDE REDUCTASE COMPLEX

The genes (dms) encoding the dimethylsulfoxide reductase protein compl ex have been cloned and sequenced from Haemophilus influenzae (Hi) typ e b (Hib) strain Eagan, The Hib dms genes are arranged as an operon wh ose genomic organization is similar to that of the Escherichia coli (E c) dmsABC operon, The deduced Hib DmsA, DmsB and DmsC amino-acid seque nces are highly homologous to their Ec counterparts and nearly identic al to the recently published sequences of the Hi type-d strain Rd Dms proteins. Hi dimethylsulfoxide reductase appears to be a new member of the superfamily of oxidoreductase enzymes.