Objectives. To define the possible cause of failure and the eventual p
otential of the bladder in 23 exstrophy patients, who underwent more t
han two failed prior attempts at closure. Methods. Twenty-three patien
ts were selected from the exstrophy data base who had two or more prio
r closures. Eighteen patients had undergone 2 previous closures and 5
patients 3 previous closures for either complete dehiscence or signifi
cant prolapse, At the time of initial closure, 19 patients did not hav
e an osteotomy. At secondary closure, 10 underwent osteotomy while at
third closure 5 had an osteotomy. At the time of reclosure at our inst
itution all underwent an osteotomy. Results. Reoperative repair at our
institution was successful in all patients. Six patients achieved a b
ladder size suitable for bladder neck reconstruction and of them 3 are
dry. The bladder size was inadequate in 9 patients and 8 are being mo
nitored for possible bladder growth. Conclusions. Tension-free closure
with osteotomy and immobilization are important factors both in an in
itial or any subsequent closure. The chance of obtaining an adequate b
ladder capacity for bladder neck plasty and eventual continence, follo
wing multiple reclosures, is markedly diminished.