Despite the strong theoretical foundation the Bayesian probabilistic a
pproach to model uncertainty in medicine meets many difficulties at th
e implementation step. One of these difficulties is related to a large
amount of conditional probabilities to be assessed and in many cases
this task was recognised to be practically insoluble. The MYCIN certai
nty factors model is a widely distributed pragmatical approach for mod
eling reasoning under uncertainty that substantially simplifies the pr
oblem, at the sacrifice of theoretical soundness. One can determine ce
rtainty factors as a function of prior and posterior probability. Howe
ver, this approach is only consistent with the modularity axiom for ce
rtainty factors for tree-structure inference networks, which is rarely
true for practical applications. In this paper we abandon the require
ment of a direct probabilistic interpretation of certainty factors and
build a model of propagation of uncertainty in terms of absolute beli
ef and belief updates. We describe our model for propagating uncertain
ty in terms of matrix multiplication with specifically defined additio
n and multiplication which correspond to parallel and sequential combi
nations of certainty factors. It is possible to define these operation
s in such a manner that they form a field, and therefore to obtain som
e useful properties. Finally we present a method of determining certai
nty factors from statistical data using nonlinear regression and illus
trate it with a leukemia diagnostics problem.