INTERFERONS INDUCE ACCUMULATION OF DIADENOSINE TRIPHOSPHATE (AP(3)A) IN HUMAN CULTURED-CELLS

Authors
VARTANIAN A NAROVLYANSKY A AMCHENKOVA A TURPAEV K KISSELEV L
Citation
A. Vartanian et al., INTERFERONS INDUCE ACCUMULATION OF DIADENOSINE TRIPHOSPHATE (AP(3)A) IN HUMAN CULTURED-CELLS, FEBS letters, 381(1-2), 1996, pp. 32-34
Citations number
19
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
381
Issue
1-2
Year of publication
1996
Pages
32 - 34
Database
ISI
SICI code
0014-5793(1996)381:1-2<32:IIAODT>2.0.ZU;2-I
Abstract
After incubation of human monocytes J96 and human myeloid leukemia HL6 0 cells with interferons (IFN) alpha or gamma, the Ap(3)A concentratio n considerably increases in parallel with accumulation of tryptophanpl -tRNA synthetase (TrpRS, EC 6.1.1.2) The Ap(3)A formation in response to IFNs is catalysed by an excessive amount of TrpRS. Although the Ap( 3)A function still remain unknown its accumulation may imply the Ap(3) A involment in the IFN-signalling pathway.