AUTOMATED SOFTWARE PACKAGE FOR ICOSAHEDRAL VIRUS RECONSTRUCTION

The three-dimensional reconstruction of icosahedral viruses from elect ron micrograph images has become an important tool for understanding v irus structure, function, and pathogenesis. We have developed an integ rated suite of software programs to automate most of the operations in volved in producing these reconstructions from EM images. Our package combines the analytical capabilities of preexisting algorithms togethe r with approaches we have developed to produce an interactive working environment which enhances the efficiency and usefulness of this appro ach to the structural analysis of icosahedral viruses. (C) 1996 Academ ic Press, Inc.