A RACIAL DIFFERENCE IN THE PREVALENCE OF THE ARG506-]GLN MUTATION

Several recent studies have reported that the factor V Arg506-->Gln mu tation is present in 3-10% of adults of European descent. To determine if the prevalence is comparable among Blacks, we have initiated a cas e-control study in a large urban hospital in Atlanta which serves a su bstantial black population. We have evaluated 131 black subjects with confirmed venous or arterial thrombosis and 61 black subjects without a history of thrombosis. Only one case and one control were positive f or the Arg506-->Gln mutation. We conclude that the mutation is more co mmon among Whites than Blacks.