ASCORBIC-ACID PREFERENTIALLY ENHANCES TYPE-I AND TYPE-III COLLAGEN GENE-TRANSCRIPTION IN HUMAN SKIN FIBROBLASTS

Authors
TAJIMA S PINNELL SR
Citation
S. Tajima et Sr. Pinnell, ASCORBIC-ACID PREFERENTIALLY ENHANCES TYPE-I AND TYPE-III COLLAGEN GENE-TRANSCRIPTION IN HUMAN SKIN FIBROBLASTS, Journal of dermatological science, 11(3), 1996, pp. 250-253
Citations number
24
Categorie Soggetti
Dermatology & Venereal Diseases
Journal title
Journal of dermatological science → ACNP
ISSN journal
09231811
Volume
11
Issue
3
Year of publication
1996
Pages
250 - 253
Database
ISI
SICI code
0923-1811(1996)11:3<250:APETAT>2.0.ZU;2-K
Abstract
Ascorbic acid is a potent stimulator for type I and III collagen expre ssions in human skin fibroblasts; stimulation of type I and III collag en synthesis and their mRNA levels by ascorbic acid has been reported previously. Nuclear run-on experiments demonstrated that ascorbic acid enhanced the transcription of type I and III collagen genes 4- and 3. 4-fold respectively, whereas transcription of type IV collagen was sli ghtly stimulated (1.7-fold). The results suggest that ascorbic acid pr eferentially enhanced type I and III collagen gene transcription.