NMR-STUDIES OF THE CONFORMATION OF DESTRUXIN-A IN WATER AND IN ACETONITRILE

The conformation of destruxin A in solution in H2O and in (CH3CN)-H-2 was determined by distance geometry calculations with inter-proton dis tance constraints derived from nuclear Overhauser enhancements in the rotating frame. The conformation is essentially independent of the sol vent used and closely resembles that found in crystals obtained from b enzene.