PROLONGATION OF MURINE CARDIAC ALLOGRAFT SURVIVAL BY MICROSPHERES CONTAINING TNF-ALPHA AND IL1-BETA NEUTRALIZING ANTIBODIES

Authors
GERBER DA OETTINGER CW DSOUZA M MILTON GV LARSEN CP PEARSON TC
Citation
Da. Gerber et al., PROLONGATION OF MURINE CARDIAC ALLOGRAFT SURVIVAL BY MICROSPHERES CONTAINING TNF-ALPHA AND IL1-BETA NEUTRALIZING ANTIBODIES, Journal of drug targeting., 3(4), 1995, pp. 311-315
Citations number
19
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of drug targeting. → ACNP
ISSN journal
1061186X
Volume
3
Issue
4
Year of publication
1995
Pages
311 - 315
Database
ISI
SICI code
1061-186X(1995)3:4<311:POMCAS>2.0.ZU;2-F
Abstract
Efficient delivery of therapeutic agents to a critical microenvironmen t may increase the efficacy of drugs used to modulate the allograft re jection response. This study demonstrates the ability of the combinati on of microspheres containing neutralizing anti-TNF alpha and anti-IL1 -beta antibodies to significantly prolong murine cardiac allograft sur vival. These results suggest that the microsphere technique is an effi cacious method to target antibody delivery to prolong allograft surviv al.