SODIUM NONIVAMIDE ACETATE - A NON-PUNGENTLY ANTINOCICEPTIVE CAPSAICINDERIVATIVE WITH UNUSUAL ANTIINFLAMMATORY PROPERTIES

1. Bradykinin induced vascular pain in conscious rats, hyperalgesia in the rat hind paw, rat hind paw edema induced by compound 48/80 and ca rrageenin and dye exudation induced by intraperitoneal injection of 0. 7% acetic acid in mice were all inhibited by sodium nonivamide acetate (SNA). 2. Collagen and arachidonic acid-induced rabbit platelet aggre gations were inhibited by SNA and capsaicin. In human platelet microso mes, prostaglandin E(2) formation in arachidonic acid metabolite was n ot inhibited by SNA but was inhibited by capsaicin and indomethacin; t hromboxane B-2 formation and its synthetase activity were inhibited by SNA and capsaicin. 3. In the extracellular recording, SNA could not d ecrease the action potential amplitude of the vagus nerve. 4. The moto r activity of mice induced by caffeine (1.0 mg/kg) was inhibited by SN A and capsaicin.