MULTIPLE SENSORY AND FUNCTIONAL-EFFECTS OF NONPHENOLIC AMINODIMETHYLENE NONIVAMIDE - AN APPROACH TO CAPSAICIN ANTAGONIST

1. Hexylaminodimethylene nonivamide (CAPCNC6, 0.1-10 mu M) inhibited t he contractility of isolated guinea pig right atria, toxically reveale d positive inotropic, chronotropic and then a cardiac arrest effect at 100 mu M and inhibited capsaicin (1.0 mu M) induced cardiotonic effec ts. 2. CAPCNC6 (0.1-10 mu M)-induced aorta contractions were inhibited in the presence of flunarizine, atropine, phentolamine, Ca2+-free sol ution and pre-treatment of the animal with capsaicin. 3. CAPCNC6 (1.0- 300 mu M)-induced trachea contractions were inhibited in the presence of capsazepine, ruthenium red, hCGRP(8.37) and pre-treatment of the an imal with capsaicin.