CEFACLOR CONCENTRATION IN PUS FROM ABSCESS CAUSED BY ODONTOGENIC INFECTION AFTER A SINGLE ORAL-ADMINISTRATION

1. Cefaclor concentrations in serum and pus from abscess of odontogeni c infection after a single oral administration of 500 mg cefaclor were assayed and pus concentrations were compared with minimum inhibitory concentration (MIG) of oral streptococci isolated from odontogenic inf ection. 2. The mean peak concentrations in serum and pus were found at identical times, 1.5 hr after administration, which were 7.22 and 0.7 2 mu g/ml, respectively.3. The mean ratio of pus:serum concentration a t the peak time was 0.10. 4. Most cefaclor concentrations in pus at th e peak time (seven of nine cases) exceeded the MIC for 90% of oral str eptococci (0.5 mu g/ml).