THE DRUG-BINDING ACTIVITY OF THE MULTIDRUG-RESPONDING TRANSCRIPTIONALREGULATOR BMRR RESIDES IN ITS C-TERMINAL DOMAIN

Authors
MARKHAM PN AHMED M NEYFAKH AA
Citation
Pn. Markham et al., THE DRUG-BINDING ACTIVITY OF THE MULTIDRUG-RESPONDING TRANSCRIPTIONALREGULATOR BMRR RESIDES IN ITS C-TERMINAL DOMAIN, Journal of bacteriology, 178(5), 1996, pp. 1473-1475
Citations number
12
Categorie Soggetti
Microbiology
Journal title
Journal of bacteriology → ACNP
ISSN journal
00219193
Volume
178
Issue
5
Year of publication
1996
Pages
1473 - 1475
Database
ISI
SICI code
0021-9193(1996)178:5<1473:TDAOTM>2.0.ZU;2-P
Abstract
Rhodamine and tetraphenylphosphonium, the substrates of the Bacillus s ubtilis multidrug efflux transporter Bmr, induce the expression of Bmr through direct interaction with its transcriptional activator BmrR. H ere we show that the C-terminal domain of BmrR, expressed individually , binds both these compounds and therefore can be used as a model for molecular analysis of the phenomenon of multidrug recognition.