ALTERATIONS OF INOSITOL PHOSPHATE TURNOVER IN STRIATUM OF AGED RATS

Authors
SUGAWA M
Citation
M. Sugawa, ALTERATIONS OF INOSITOL PHOSPHATE TURNOVER IN STRIATUM OF AGED RATS, European journal of pharmacology. Molecular pharmacology section, 247(1), 1993, pp. 39-44
Citations number
49
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology. Molecular pharmacology section → ACNP
ISSN journal
09224106
Volume
247
Issue
1
Year of publication
1993
Pages
39 - 44
Database
ISI
SICI code
0922-4106(1993)247:1<39:AOIPTI>2.0.ZU;2-L
Abstract
Age-related inositol phosphate turnover in the rat central nervous sys tem was investigated. Higher phospholipase-C activity and drastically higher (almost 2.5-fold) inositol 1,4,5-trisphosphate concentration in the corpus striatum (caudate-putamen) of extremely old (approximately 40 months) female Wistar rats in comparison to the young adult (appro ximately 3.5 months) rats were observed. Dopamine seems to slightly in hibit total inositol phosphate formation and this effect was antagoniz ed by (-)-sulpiride.