CHRONIC ETHANOL EXPOSURE POTENTIATES MUSCARINIC RECEPTOR AND ALPHA(2)-ADRENOCEPTOR-MEDIATED INHIBITION OF CAMP ACCUMULATION IN PC-12 CELLS

Authors
KIM WK HAWTHORN MH RABIN RA
Citation
Wk. Kim et al., CHRONIC ETHANOL EXPOSURE POTENTIATES MUSCARINIC RECEPTOR AND ALPHA(2)-ADRENOCEPTOR-MEDIATED INHIBITION OF CAMP ACCUMULATION IN PC-12 CELLS, European journal of pharmacology. Molecular pharmacology section, 247(1), 1993, pp. 89-92
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology. Molecular pharmacology section → ACNP
ISSN journal
09224106
Volume
247
Issue
1
Year of publication
1993
Pages
89 - 92
Database
ISI
SICI code
0922-4106(1993)247:1<89:CEEPMR>2.0.ZU;2-I
Abstract
The effects of ethanol on receptor-mediated inhibition of cAMP product ion were investigated in PC 12 cells. The in vitro addition of ethanol enhanced N-ethylcarboxyadenosine (NECA)-stimulated cAMP production wi thout altering the inhibitory action of carbachol or epinephrine. A 4 day exposure of PC 12 cells to ethanol decreased the stimulation of cA MP production by NECA, but increased the inhibition of NECA-stimulated cAMP production by carbachol and epinephrine.