DIBEFURIN, A NOVEL FUNGAL METABOLITE INHIBITING CALCINEURIN PHOSPHATASE-ACTIVITY

Authors
BRILL GM PREMACHANDRAN U KARWOWSKI JP HENRY R CWIK DK TRAPHAGEN LM HUMPHREY PE JACKSON M CLEMENT JJ BURRES NS KADAM S CHEN RH MCALPINE JB
Citation
Gm. Brill et al., DIBEFURIN, A NOVEL FUNGAL METABOLITE INHIBITING CALCINEURIN PHOSPHATASE-ACTIVITY, Journal of antibiotics, 49(2), 1996, pp. 124-128
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
49
Issue
2
Year of publication
1996
Pages
124 - 128
Database
ISI
SICI code
0021-8820(1996)49:2<124:DANFMI>2.0.ZU;2-5
Abstract
The novel calcineurin inhibitor, dibefurin, has been isolated from the fungal culture AB 1650I-759. The isolation was bioactivity-directed f ractionation using an assay which measures the phosphatase activity of calcineurin. The compound was purified by countercurrent, reverse pha se and gel filtration chromatographies. Several studies, including cry stallographic, NMR and MS, revealed that dibefurin is a novel dimeric compound of a unique structural type.