CHEMICAL MODIFICATION OF PA-48153C, A NOVEL IMMUNOSUPPRESSANT ISOLATED FROM STREPTOMYCES PRUNICOLOR PA-48153

Authors
YASUI K TAMURA Y NAKATANI T HORIBE I KAWADA K KOIZUMI K SUZUKI R OHTANI M
Citation
K. Yasui et al., CHEMICAL MODIFICATION OF PA-48153C, A NOVEL IMMUNOSUPPRESSANT ISOLATED FROM STREPTOMYCES PRUNICOLOR PA-48153, Journal of antibiotics, 49(2), 1996, pp. 173-180
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
49
Issue
2
Year of publication
1996
Pages
173 - 180
Database
ISI
SICI code
0021-8820(1996)49:2<173:CMOPAN>2.0.ZU;2-X
Abstract
5 beta-Methoxy (20), 14-methyl (24), 14,14-dibromo-15-nor (25), 8-O-ac yl (26 similar to 45), 8-O-alkyl (46), 8-O-alkoxycarbonyl (47, 48), an d 8-O-carbamoyl (49) derivatives of PA-48153C, a novel immunosuppressa nt isolated from fermentation products of Streptomyces prunicolor PA-4 8153, were prepared. These compounds were found to retain the inhibito ry activity on the responses of both T and B cells to mitogens. Among them, the C-8 hexanoate 28 showed potent suppressive effects on mitoge n responses with less cytotoxicity to EL4 cells and was selected for i n vivo evaluation.