THE POTENTIAL OF PHOSPHINIMINES AS BUILDING-BLOCKS FOR A NEW-GENERATION OF RADIOPHARMACEUTICALS

Authors
KATTI KV SINGH PR KATTI KK BARNES CL KOPICKA K KETRING AR VOLKERT WA
Citation
Kv. Katti et al., THE POTENTIAL OF PHOSPHINIMINES AS BUILDING-BLOCKS FOR A NEW-GENERATION OF RADIOPHARMACEUTICALS, Phosphorus, sulfur and silicon and the related elements, 75(1-4), 1993, pp. 55-58
Citations number
4
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Phosphorus, sulfur and silicon and the related elements → ACNP
ISSN journal
10426507
Volume
75
Issue
1-4
Year of publication
1993
Pages
55 - 58
Database
ISI
SICI code
1042-6507(1993)75:1-4<55:TPOPAB>2.0.ZU;2-P
Abstract
Reaction of Ph3P = NSiMe3 with NH4ReO4 produced the ion pair Ph3P = NH 2+ReO4- which was characterized by spectroscopic data and X-ray crysta llography. The thermolysis of this ion pair gave the neutral Re(VII) c omplex: Ph3P = N-ReO3 in good yields. The reactions of (TcO4-)-Tc-99m Or (ReO4-)-Re-188 with Ph3P = N-SiMe3 also produced the metallic radio isotope analogues of the ion pair: Ph3P = NH2+MO4- (M = Tc-99m or Re-1 88) which on heating produce the neutral species Ph3P = N-MO3 (M = Tc- 99m or Re-188). The implications of such small molecule Tc-99m or Re-1 88 complexes for the development of a new genre of radiopharmaceutical s will be discussed.