(E)-(METHYLOXYIMINO)ACETAMIDES AS ANALOGS OF NEUROLEPTIC BENZAMIDES -SYNTHESIS AND D-2-DOPAMINERGIC BINDING-AFFINITY

Some type C (E)-(methyloxyimino)acetamides were synthesised as analogu es of type A neuroleptic and antipsychotic benzamides, in which the ar omatic group is substituted by a methyloxyiminomethyl moiety with the E configuration (CH2ON = CH, E-MOIMM). Type C compounds were tested fo r their D-2-dopaminergic binding affinity in order to obtain an indica tion of their potential neuroleptic and antipsychotic properties. Biol ogical results Showed that only a few aryl-substituted E-MOIM derivati ves possess a certain affinity for the D-2-dopaminergic receptor, at l east one order of magnitude lower than that of metoclopramide and sulp iride.