SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF BENZO[A]DIHYDROCARBAZOLE AND BENZOTETRAHYDROCYCLOHEPT[1,2-B]INDOLE DERIVATIVES

Authors
MACCHIA M MANERA C NENCETTI S ROSSELLO A BROCCALI G LIMONTA D
Citation
M. Macchia et al., SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF BENZO[A]DIHYDROCARBAZOLE AND BENZOTETRAHYDROCYCLOHEPT[1,2-B]INDOLE DERIVATIVES, Il Farmaco, 51(1), 1996, pp. 75-78
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
51
Issue
1
Year of publication
1996
Pages
75 - 78
Database
ISI
SICI code
0014-827X(1996)51:1<75:SAAAOB>2.0.ZU;2-W
Abstract
A certain number of benzodihydrocarbazoles and benzotetrahydrocyclohep tindoles were synthesized and tested for their antimicrobial activity. Compounds substituted on the nitrogen of the tetracyclic systems with a dimethylaminopropyl chain showed an antibacterial activity directed almost exclusively towards Gram-positive bacteria, while their N-unsu bstituted analogs were completely inactive.