CHRONIC HERPES-GESTATIONIS AND ANTIPHOSPHOLIPID ANTIBODY SYNDROME SUCCESSFULLY TREATED WITH CYCLOPHOSPHAMIDE

Herpes gestationis shares many features with other bullous diseases, e specially bullous pemphigoid. Treatments of benefit in bullous pemphig oid may also be effective for herpes gestationis. Cyclophosphamide, az athioprine, and other immunosuppressive agents have been used successf ully in refractory cases of bullous pemphigoid. We describe a patient with severe and persistent herpes gestationis in the postpartum period and the antiphospholipid antibody syndrome, both of which were refrac tory to high-dose corticosteroid therapy. Treatment with pulsed-dose i ntravenous cyclophosphamide produced an excellent clinical response.