In this retrospective review we assessed the frequency with which atyp
ical glandular cells in cervical smears predict cervical glandular les
ions. Asymptomatic patients (n=34) with one or more smears showing aty
pical glandular cells and subsequent histopathological assessment were
studied. Independent cytological and histological review was undertak
en. Cytological review confirmed atypical glandular cells in 29 cases,
17 of which had coexisting squamous dyskaryosis. Histological review
of these 29 cases revealed glandular neoplasia in 13 (45%) and microgl
andular hyperplasia (MEH) in an additional four (14%). Initial reporti
ng had underestimated the prevalence of glandular neoplasia.