COMPARATIVE ACTIVITY OF PIPERACILLIN TAZOBACTAM AGAINST 5625 ISOLATESFROM HOSPITALIZED-PATIENTS/

The comparative activities of piperacillin/tazobactam and other antibi otics against 5625 Gram-negative and Gram-positive bacteria freshly is olated from hospitalized patients was examined. The percentage of Ente robacteriaceae susceptible to piperacillin/tazobactam, ceftazidime, im ipenem and ciprofloxacin was very similar and varied from 81% to 84% i n the Enterobacteriaceae with inducible type 1 beta-lactamases and fro m 93 to 97% in the non-inducible organisms. Piperacillin/tazobactam wa s similar in activity to ceftazidime against Pseudomonas aeruginosa an d more active than imipenem or ciprofloxacin. Piperacillin/tazobactam is more active than ceftazidime against Gram-positive bacteria (staphy lococci, enterococci) and seems to be a promising antibiotic for nosoc omial infections.