HISTOLOGICAL-FINDINGS OF HUMAN LEPROSY PERIAPICAL GRANULOMAS

Histological analysis of human leprosy periapical granulomas was condu cted to study the histological responses to Mycobacterium leprae, Many Langhans-type giant cells and epithelioid cell tubercles were observe d, although M. leprae were not detected in leprosy periapical granulom as, Although numerous T- and B-cells were infiltrated in leprosy peria pical granuloma, the T-/B-cell ratio of leprosy is not changed to that of periapical granulomas isolated from normal patients, These finding s suggested that human leprosy periapical granulomas develop as a resu lt of immunological responses to M. leprae.