EFFECTS OF HISTAMINE ON GIZZARD EROSIONS AND ON THE ACTIVITY OF SELECTED ENZYMES IN CHICKENS

Dose- (5, 10 and 15 mg/kg body mass) and time-dependent (2, 6, 12 and 24 h after treatment) effects of histamine on gizzard lesions and seru m AST, ALT and CK activities of chickens are reported. Morphometric re sults and histopathological examination revealed that the most effecti ve histamine dose which induced severe gizzard lesions was 10 mg/kg b. m., especially 2, 6 and 12 h after administration. No difference from the control values was found after 24 h. That dose also induced an ele vation of serum enzyme (AST, ALT, CK) activities, which was most expre ssed for the activity of ALT.